∫Integrated Systems Health
INTEGRATED SYSTEMS HEALTH · MASTER COURSE · v1.0

Modern, holistic,
functional health.

Learn how microbiome ecology, peptide signaling, autonomic regulation, genomics, epigenomics, and lab testing interact — and how to translate them into evidence-graded clinical reasoning.

Start the curriculum Explore the genomics pillar
20
modules
5
clinical pillars
3
learner tracks
150+
graded claims
100+
lab & genomic test cards
14
clinical cases
Five clinical pillars

One integrated model.

Ecological & metabolic interface

Microbiome

Ecology, metabolites, barrier function, immune signaling, diet, probiotics, prebiotics, postbiotics, FMT/live biotherapeutics, and microbiome testing.

  • SCFAs
  • Bile acids
  • Mucosal immunity
  • Diet × microbes
Signaling molecules & therapeutic messengers

Peptides

Endogenous signals, therapeutic peptides, GLP-1/GIP, endocrine regulation, safety, monitoring, and regulation.

  • GLP-1 / GIP
  • Growth axis
  • BPC-157 evidence
  • Safety & sourcing
Neural regulation & neuroimmune feedback

Vagus & Autonomic

Autonomic physiology, gut–brain signaling, inflammatory reflex, HRV, VNS, tVNS, behavioral regulation, and device evidence.

  • Inflammatory reflex
  • HRV
  • tVNS / VNS
  • DGBI
Inherited blueprint & expression layer

Genomics & Epigenomics

Inherited risk, gene expression, pharmacogenomics, nutrigenomics, polygenic risk, family history, epigenetic modulation, and gene-targeted therapies — interpreted with caution, counseling, and clinical actionability.

  • Actionable variants
  • Pharmacogenomics
  • Polygenic risk
  • Epigenome levers
Feedback, safety & early-warning

Lab Testing

Baseline safety, diagnostic triage, microbiome testing, metabolic markers, peptide monitoring, autonomic metrics, genomic confirmation, and biomarker follow-up.

  • ApoB / Lp(a)
  • HbA1c / insulin
  • Inflammation
  • Hormones

The integrated model

Inherited genome
      ↓
Variant risk architecture
      ↓
Epigenome + transcriptome + proteome + metabolome
      ↓
Microbiome / inflammation / peptides / autonomic tone / environment
      ↓
Clinical phenotype
      ↓
Labs, symptoms, imaging, family history, outcomes
      ↓
Prevention · monitoring · treatment · referral · gene-targeted therapy

Genomics & Epigenomics

Read genome reports responsibly. Distinguish actionable from speculative.

Evidence Grader

150+ graded claims across all five pillars. Find the marketing red flags.

Capstone care map

Build a five-pillar plan with referral, monitoring, and stop rules.