∫Integrated Systems Health
Curriculum

Twenty modules. Five pillars.

Modules 1–14 build the four-pillar foundation. Modules 15–19 add genomics, epigenomics, and the regulated frontier of gene-targeted therapy. Module 20 integrates everything in a capstone care map.

  1. 01

    Foundations of Integrated Systems Health

    The five-pillar model, evidence grading, and the limits of mechanism.

    MicrobiomePeptidesVagus & AutonomicGenomics & EpigenomicsLab Testing
    Five pillarsEvidence vs anecdoteReductionism vs systemsScope of practice
  2. 02

    Microbiome Ecology & Metabolites

    Communities, diversity, SCFAs, bile acids, and what testing actually shows.

    Microbiome
    Diversity metricsSCFAsBile acid poolMucus & barrier
  3. 03

    Diet, Fiber & the Microbial Diet–Phenotype Loop

    Practical nutrition for ecology, not for ideology.

    MicrobiomeLab Testing
    Fermentable fibersPolyphenolsFODMAP nuancePersonalization
  4. 04

    Probiotics, Prebiotics, Postbiotics & Live Biotherapeutics

    What the evidence actually supports — and where it doesn't.

    Microbiome
    Strain-specific claimsFMTLBPsMarketing red flags
  5. 05

    Peptide Pharmacology Foundations

    Receptor biology, half-life, sourcing, regulation, and safety.

    PeptidesLab Testing
    PK/PD basicsSourcing & purityRegulatory statusAdverse effects
  6. 06

    GLP-1, GIP & Cardiometabolic Peptides

    Evidence-graded use, monitoring, and integration with lifestyle.

    PeptidesLab Testing
    GLP-1 RAGIP/GLP-1Body compositionLong-term safety
  7. 07

    Regenerative & Investigational Peptides

    BPC-157, TB-500, thymosin family — separating signal from hype.

    Peptides
    Mechanism claimsTrial maturityRisk communication
  8. 08

    Vagus & Autonomic Physiology

    Anatomy, the inflammatory reflex, HRV, and clinical phenotypes.

    Vagus & Autonomic
    Afferent / efferentHPA axisHRV interpretation
  9. 09

    VNS, tVNS & Behavioral Regulation

    Devices, breathwork, gut-directed hypnosis — what works for whom.

    Vagus & Autonomic
    Implanted VNSAuricular tVNSSlow breathingCBT/GDH
  10. 10

    Disorders of Gut–Brain Interaction

    IBS, functional dyspepsia, and the autonomic–microbial overlap.

    Vagus & AutonomicMicrobiome
    Rome criteriaVisceral hypersensitivityBehavioral therapy
  11. 11

    Lab Testing Foundations

    Baseline panels, pre-test probability, and avoiding test cascades.

    Lab Testing
    CBC/CMPLipids beyond LDL-CInflammation panelHormones
  12. 12

    Functional & Specialty Testing — Critical Read

    Stool, organic acids, food sensitivity — where they help and where they mislead.

    Lab TestingMicrobiome
    GI-MAP-style panelsOATIgG food panels caveats
  13. 13

    Hormonal & Metabolic Monitoring

    Thyroid, sex hormones, insulin, fasting markers, body composition.

    Lab TestingPeptides
    TSH/fT4/fT3Sex hormonesHOMA-IRDEXA
  14. 14

    Integrating Microbiome × Peptides × Vagus × Labs

    Building the four-pillar care map before genomics layers in.

    MicrobiomePeptidesVagus & AutonomicLab Testing
    PhenotypingSequencing interventionsOutcome metrics
  15. 15

    Genomics for Functional & Systems Medicine

    Genome vs epigenome vs phenotype, family history, and the limits of testing.

    Genomics & EpigenomicsLab Testing
    Germline vs somaticPenetranceDTC vs clinicalThree-generation pedigree
  16. 16

    Early-Warning Genetics & Preventive Care

    Identifying inherited risk before disease becomes clinically obvious.

    Genomics & EpigenomicsLab Testing
    HBOC / Lynch / FHCardiomyopathy / channelopathiesCascade testingPolygenic context
  17. 17

    Pharmacogenomics, Peptides & Precision Prescribing

    Translating PGx into safer prescribing without abandoning monitoring.

    Genomics & EpigenomicsPeptidesLab Testing
    CYP2D6/2C19/2C9HLA riskDPYD/TPMT/NUDT15CPIC workflow
  18. 18

    Nutrigenomics, Microbiome & Functional Genomics

    Practical, cautious integration of gene–nutrient–microbe interactions.

    Genomics & EpigenomicsMicrobiomeLab Testing
    MTHFR overclaimingAPOE / LCT / ALDH2 / HFEFUT2 caveatsMicrobe → epigenome
  19. 19

    Epigenome Modulation & Gene-Targeted Therapies

    Influencing expression with lifestyle — and the regulated frontier of CRISPR, RNA, and gene therapy.

    Genomics & EpigenomicsMicrobiomePeptidesVagus & AutonomicLab Testing
    Modifiable epigenetic inputsMethylation clocks caveatsCRISPR / AAV / ASO / siRNASpecialist referral
  20. 20

    Capstone: Integrated Genomic Care Map

    Build a full five-pillar care map with evidence grading and referral logic.

    MicrobiomePeptidesVagus & AutonomicGenomics & EpigenomicsLab Testing
    Phenotype → tests → planEvidence grading per claimStop / refer / escalate
Looking for the integrated case? Head to the capstone.